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Alpha-Beta Blockers for High Blood Pressure

Alpha-beta blockers, also called nervous system inhibitors or centrally acting drugs, reduce nerve impulses to blood vessels the same way alpha blockers do, but they also slow the heartbeat, as beta blockers do. As a result, blood pressure goes down.

Methyldopa is indicated specifically for use during pregnancy and is otherwise not used. Do not use methyldopa if you have impaired liver or kidney function. Side effects can include depression, nightmares, dry mouth, and drowsiness. We wary of adverse mental effects.

Reserpine is often used in primary (uncomplicated) hypertension. It is cost effective drug, but has in past been associated with undesirable side effects such as depression. New low-dosage regiments have mitigated the adverse side-effects while still providing good anti-hypertensive treatment. Do not use Reserpine if you have depression. Side effects may include drowsiness, headache, dizziness, and nasal congestion. Avoid driving and operating heavy machinery when first starting treatment with Reserpine.

Central alpha-2 agonists

Clonidine (Catapres†)

0.1-0.8

2

Other centrally acting drugs

Clonidine Patch (Catapres-Tts)

0.1-0.3

1 wkly

Methyldopa (Aldomet†)

250-1,000

2

Reserpine (Generic)

0.1-0.25

1

Guanfacine (Tenex†)

0.5-2

1


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